他汀类药物是历史上处方量最大的药物。9200万美国人服用他汀类药物。全球年销售额超过200亿美元。它们被认为非常重要，以至于一些医生提倡像在饮用水中添加氟化物一样在饮用水中添加它们。他汀类药物的实际作用机制如下：根据最乐观的荟萃分析，每日服用该药物，五年内可延长预期寿命3-4天。这不是每年延长3-4天，而是连续服用1825天后总共延长3-4天。- 五分之一服用他汀类药物的人会出现严重的副作用：肌肉疼痛、肝损伤、认知障碍、糖尿病风险增加、神经病变或疲劳。所以，你每天服用一片药，持续 5 年，有 20% 的几率出现严重副作用，平均可以延长 3-4 天的预期寿命。制药业使之成为人类历史上最畅销的药物类别。这种机制使情况变得更糟：他汀类药物会阻断甲羟戊酸途径中的HMG-CoA还原酶。该途径不仅产生胆固醇，还产生：辅酶Q10（心脏能量）- 维生素K2（动脉健康）- 多萜醇（细胞信号传导）- 血红素A（氧气运输）你服用的不是降胆固醇药物，而是会破坏新陈代谢的药物，降低胆固醇只是它的副作用。最初批准他汀类药物上市的临床试验显示，其疗效甚微，主要针对已经发生过心脏病发作的患者。之后，适应症不断扩大。现在，即使没有心脏病史、血压正常、身体健康的人，也会“预防性地”服用这种药物，因为一项计算出的风险评分表明，他们可能在 10 年内出现问题。医生开这些药是因为指南建议这样做。指南之所以建议这样做，是因为制药公司资助了制定这些指南的研究。而撰写这些指南的研究人员与他汀类药物生产商存在经济利益关系。此事已有记录。此事已公开。此事属正常现象。每天有 9200 万美国人服用这些药物，而心脏病发病率却保持不变，制药公司却数着数十亿美元的利润。最大的骗局不是他汀类药物无效，而是他们让全世界都相信每个人都需要服用这种药物。Statins are the most prescribed medication in history. 92 million Americans take them. Global sales exceed 20 billion dollars annually.They're considered so essential that some doctors advocate putting them in the water supply like fluoride.Here's what statins actually do:- They extend life expectancy by 3-4 days over 5 years of daily use according to the most optimistic meta-analyses. That's not 3-4 days per year. That's 3-4 days total after 1,825 days of taking the medication.- One in five people on statins experiences significant side effects: muscle pain, liver damage, cognitive impairment, increased diabetes risk, neuropathy, or fatigue.So you take a pill every day for 5 years, have a 20% chance of serious side effects, and gain 3-4 days of life expectancy on average.The pharmaceutical industry made this the best-selling drug in human history.The mechanism makes it worse: Statins block HMG-CoA reductase in the mevalonate pathway. This pathway doesn't just produce cholesterol. It produces:- CoQ10 (heart energy)- Vitamin K2 (arterial health)- Dolichols (cell signaling)- Heme A (oxygen transport)You're not taking a cholesterol drug. You're taking a metabolic wrecking ball that happens to lower cholesterol as a side effect.The original trials that got statins approved showed minimal benefit, mostly in people who'd already had heart attacks. Then the indications expanded. And expanded. And expanded.Now they're prescribed "preventively" to people with zero cardiac history, normal blood pressure, and good health because one calculated risk score says maybe possibly they might have a problem in 10 years.Doctors prescribe them because guidelines say to. Guidelines say to because pharmaceutical companies funded the research that set the guidelines. The researchers who wrote the guidelines have financial relationships with statin manufacturers.This is documented. This is public. This is normal.And 92 million Americans take the pills every day while rates of heart disease remain unchanged and pharmaceutical companies count their billions.The greatest scam isn't that statins don't work. The greatest scam is that they convinced the world that everyone needs to be on them.
